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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PHGDH
All Species:
36.36
Human Site:
S280
Identified Species:
57.14
UniProt:
O43175
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43175
NP_006614.2
533
56651
S280
V
D
H
E
N
V
I
S
C
P
H
L
G
A
S
Chimpanzee
Pan troglodytes
A5A6P1
533
56644
S280
V
D
H
E
N
V
I
S
C
P
H
L
G
A
S
Rhesus Macaque
Macaca mulatta
XP_001114128
533
56466
S280
V
D
H
E
N
V
I
S
C
P
H
L
G
A
S
Dog
Lupus familis
XP_849835
533
56527
S280
V
E
H
E
R
V
I
S
C
P
H
L
G
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61753
533
56567
S280
V
D
H
E
N
V
I
S
C
P
H
L
G
A
S
Rat
Rattus norvegicus
O08651
533
56475
S280
V
D
H
E
N
V
I
S
C
P
H
L
G
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515318
533
55943
S280
V
N
H
P
N
V
I
S
C
P
H
L
G
A
S
Chicken
Gallus gallus
XP_422226
525
55022
C280
V
D
H
P
N
V
I
C
C
P
H
L
G
A
S
Frog
Xenopus laevis
NP_001091250
509
53841
S281
V
E
H
P
L
V
I
S
L
P
H
L
G
A
S
Zebra Danio
Brachydanio rerio
NP_955871
527
55379
S280
V
N
H
P
N
V
I
S
C
P
H
L
G
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_609496
332
35216
T110
S
I
S
A
C
E
L
T
C
I
L
I
G
S
L
Honey Bee
Apis mellifera
XP_001121753
478
51893
N246
V
D
E
E
A
L
L
N
A
L
K
S
G
H
C
Nematode Worm
Caenorhab. elegans
NP_496868
322
34673
A101
L
V
M
N
T
P
Q
A
N
S
R
S
A
A
E
Sea Urchin
Strong. purpuratus
XP_001203904
493
51557
V243
I
Q
H
P
K
V
I
V
T
P
H
L
G
A
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04130
624
66436
V357
I
Q
H
E
N
V
T
V
T
P
H
L
G
A
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
92.5
N.A.
94.5
94.1
N.A.
82.5
67.5
56.2
60.7
N.A.
35
45
32.6
46.3
Protein Similarity:
100
99.6
99.2
96
N.A.
97
97.1
N.A.
90.2
80.1
71.6
75.9
N.A.
48.2
61.9
45.5
61.5
P-Site Identity:
100
100
100
86.6
N.A.
100
100
N.A.
86.6
86.6
73.3
86.6
N.A.
13.3
26.6
6.6
60
P-Site Similarity:
100
100
100
93.3
N.A.
100
100
N.A.
93.3
86.6
80
93.3
N.A.
40
46.6
20
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
33.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
66.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
7
0
0
7
7
0
0
0
7
87
0
% A
% Cys:
0
0
0
0
7
0
0
7
67
0
0
0
0
0
7
% C
% Asp:
0
47
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
14
7
54
0
7
0
0
0
0
0
0
0
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
94
0
0
% G
% His:
0
0
80
0
0
0
0
0
0
0
80
0
0
7
0
% H
% Ile:
14
7
0
0
0
0
74
0
0
7
0
7
0
0
0
% I
% Lys:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% K
% Leu:
7
0
0
0
7
7
14
0
7
7
7
80
0
0
7
% L
% Met:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
14
0
7
60
0
0
7
7
0
0
0
0
0
0
% N
% Pro:
0
0
0
34
0
7
0
0
0
80
0
0
0
0
0
% P
% Gln:
0
14
0
0
0
0
7
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% R
% Ser:
7
0
7
0
0
0
0
60
0
7
0
14
0
7
80
% S
% Thr:
0
0
0
0
7
0
7
7
14
0
0
0
0
0
0
% T
% Val:
74
7
0
0
0
80
0
14
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _